Related Experiment Video
Updated: Feb 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Atopic dermatitis: phototherapy and systemic therapy
Dawn Marie Davis1, Jenna Borok2,3, Jeremy Udkoff2,3
1Department of Dermatology and Pediatrics, Mayo Clinic Rochester, Minnesota, USA. Davis.DawnMarie@mayo.edu.
Abstract:
The majority of atopic dermatitis (AD) patients respond satisfactorily to gentle bathing, frequent moisturizing, and topical medications. Second-line therapies for AD should be used in recalcitrant cases or in patients with uncontrolled disease despite compliance with first-line measures and avoidance of allergens. Recommended advanced therapies include phototherapy, especially narrowband ultraviolet B, systemic immunosuppressants, and a new biologic agent. Few studies have compared head-to-head efficacy of the different immunosuppressant therapies such as cyclosporine, methotrexate, azathioprine and mycophenolate mofetil. Therefore, the agent used is based on provider and patient preferences and can be decided on a case-by-case basis.
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