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Pain in women.

Inna Belfer1

  • 1Adjunct Professor of Human Genetics and Medicine, University of Pittsburgh, Pittsburgh, PA, USA. inna.belfer@nih.gov.

Agri : Agri (Algoloji) Dernegi'Nin Yayin Organidir = the Journal of the Turkish Society of Algology
|September 13, 2017
PubMed
Summary

Women experience pain differently than men, with higher prevalence of painful disorders. Genetic factors significantly influence these sex differences in pain and analgesia.

Area of Science:

  • Neuroscience
  • Genetics
  • Pain Research

Background:

  • Sex differences in pain perception and response are well-documented.
  • Women exhibit higher prevalence of various pain conditions compared to men.

Purpose of the Study:

  • To review the underlying mechanisms of sex differences in pain.
  • To explore genetic factors influencing pain and analgesia.

Main Methods:

  • Literature review of studies investigating sex differences in pain.
  • Analysis of genetic factors with sex-specific or sex-biased effects on pain.

Main Results:

  • Significant sex disparities exist in pain perception, pain attitudes, and pain disorder prevalence.
  • Women report higher prevalence of painful disorders (over twice that of men).

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  • Genetic factors play a crucial role in sex-specific pain modulation.

    • Conclusions:

    • Sex differences in pain are multifaceted, involving genetic, behavioral, and physiological factors.
    • Understanding these differences is vital for developing effective, sex-specific pain treatments.