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Modulation of granulocyte functions by bacterial exotoxin and endotoxins
K D Bremm1, W König, M Thelestam
1Lehrstuhl für Medizinische Mikrobiologie und Immunologie, AG Infektabwehr, Ruhr-Universität Bochum, West Germany.
Immunology
|November 1, 1987
Abstract:
The modulation of granulocyte functions by bacterial exotoxins (Streptolysin O, alveolysin, theta toxin) and endotoxins from salmonella and lipid A is described here. Incubation of polymorphonuclear granulocytes with thiol-activated toxins resulted in an increased leukotriene generation. Toxin-pretreated PMNs revealed an increased omega oxidation of LTB4, which may explain why toxin-stimulated cells release more LTC4 than LTB4. Furthermore, toxin-pretreated PMNs showed a decreased leukotriene generation on subsequent stimulation with the Ca-ionophore A 23187 or opsonized zymosan.