Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Localized bone marrow relapse in acute lymphoblastic leukemia.

B Golembe, N K Ramsay, R McKenna

    Medical and Pediatric Oncology
    |January 1, 1979
    PubMed
    Summary

    Localized bone marrow relapse in acute lymphoblastic leukemia (ALL) is rare. A case study highlights discordant bone marrow findings, suggesting localized relapse may occur even after long-term remission.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preliminary joint neutron and X-ray crystallographic study of human carbonic anhydrase II.

    Acta crystallographica. Section F, Structural biology and crystallization communications·2009
    Same author

    Correlation between Neoral 2 hours post-dose levels and histologic findings on surveillance biopsies.

    Transplantation proceedings·2004
    Same author

    Preclinical studies targeting normal and leukemic hematopoietic cells with Yttrium-90-labeled anti-CD45 antibody in vitro and in vivo in nude mice.

    Cancer biotherapy & radiopharmaceuticals·2003
    Same author

    Initial closed operation of the CELSS Test Facility Engineering Development Unit.

    Advances in space research : the official journal of the Committee on Space Research (COSPAR)·2003
    Same author

    Identification of a novel HLA-B*07 allele--HLA-B*0726.

    Tissue antigens·2002
    Same author

    Lymphoproliferative disorder presenting as pulmonary nodules after bone marrow transplantation.

    Bone marrow transplantation·2002

    Area of Science:

    • Pediatric Oncology
    • Hematology
    • Leukemia Research

    Background:

    • Acute lymphoblastic leukemia (ALL) is a common childhood cancer.
    • Long-term remission and cessation of chemotherapy are goals in ALL treatment.
    • Relapse, particularly localized bone marrow relapse, is a concern in ALL survivors.

    Observation:

    • An 11-year-old girl in remission for 6 years presented with discordant bone marrow biopsy results.
    • One sample showed significant leukemic infiltration, while another was normal.
    • Three months later, she developed bone pain and skeletal abnormalities consistent with relapse.

    Findings:

    • The patient's relapse was initially localized to specific bone marrow sites.
    • Peripheral blood counts remained normal despite bone marrow involvement.

    Related Experiment Videos

  • Reinduction therapy led to remission, indicating the efficacy of treatment for relapsed ALL.

    • Implications:

    • The case questions the current surveillance strategies for ALL relapse.
    • It highlights the potential for localized bone marrow involvement to be missed in routine follow-up.
    • Further investigation into the frequency and detection of localized bone marrow relapse is warranted before discontinuing therapy.