Related Experiment Video

Updated: Feb 23, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

17.3K

Diagnostic challenges of kidney diseases in HIV-infected patients

Robin Chazot1, Elisabeth Botelho-Nevers2,3, Anne Frésard2,3

  • 1a Department of Nephrology, Dialysis, Transplantation and Hypertension , University Hospital of Saint-Étienne , Saint-Étienne , France.

Expert Review of Anti-Infective Therapy
|September 13, 2017
PubMed

Insights

Diagnosing chronic kidney disease (CKD) in people with HIV is challenging. New kidney biomarkers show promise for early detection and predicting outcomes in HIV-positive individuals.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Biomarker Discovery

Background:

  • Chronic kidney disease (CKD) is common in people living with HIV (PLWH), increasing cardiovascular risks and mortality.
  • Early CKD diagnosis in PLWH is difficult using current standard methods.

Purpose of the Study:

  • To review diagnostic tools for CKD in PLWH.
  • To explore novel kidney biomarkers for CKD detection and prognosis in PLWH.

Main Methods:

  • Literature search on PubMed for reviews and clinical trials on kidney biomarkers in PLWH.
  • Analysis of current CKD diagnostic parameters: estimated Glomerular Filtration Rate (eGFR) and urine protein/creatinine ratio (uPCR).

Main Results:

  • Standard eGFR estimates (like CKD-EPI) have limitations in accuracy for PLWH.
  • Low-grade proteinuria is a significant predictor of kidney disease progression in PLWH.
  • Novel biomarkers such as NAG, KIM-1, and Alpha-1-microglobulin may predict progression, mortality, and antiretroviral-related tubulopathy.

Conclusions:

  • Current CKD diagnostic markers (eGFR, uPCR) have limitations in PLWH.
  • Emerging kidney biomarkers offer potential for improved CKD diagnosis, risk stratification, and management in PLWH.
  • Further research is required to validate the clinical utility of these novel biomarkers.
Abstract

Keywords:
HIVbiomarkerschronic kidney diseaseglomerular filtration ratekidney

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

754
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

5.3K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
363
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
503
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
827
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
758
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
552
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
433