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Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
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Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

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Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
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Types of Toxins01:36

Types of Toxins

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
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Drug Toxicity: Overview01:00

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Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
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Toxic Reactions: Overview01:26

Toxic Reactions: Overview

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
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Updated: Feb 23, 2026

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
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[Marijuana: A toxicological approach].

Silvia Cortese1

  • 1Adicciones, Ministerio de Salud del Gobierno de la Ciudad de Buenos Aires. División Toxicología del Hospital General de Agudos Juan A. Fernández. dra.s.cortese@gmail.com.

Vertex (Buenos Aires, Argentina)
|September 13, 2017
PubMed
Summary

Marijuana use is increasing globally, especially among adolescents. Early exposure can negatively impact cognitive development and impulse control, leading to long-term adverse effects.

Area of Science:

  • Neuroscience
  • Adolescent Medicine
  • Public Health

Background:

  • Marijuana and alcohol consumption are increasingly normalized in adult society.
  • Marijuana use has become globally widespread, with a notable presence in Argentina.
  • Adolescence represents a critical neurodevelopmental period.

Purpose of the Study:

  • To highlight the scientific approach needed to understand marijuana's toxicity.
  • To disseminate knowledge regarding the adverse effects of marijuana, particularly in adolescents.
  • To investigate the potential long-term consequences of adolescent marijuana exposure.

Main Methods:

  • Literature review on marijuana toxicity and neurodevelopment.
  • Analysis of epidemiological data on adolescent substance use.

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  • Case studies illustrating cognitive and impulse control impacts.

    • Main Results:

    • Adolescent exposure to marijuana can disrupt neurodevelopment.
    • Negative impacts are observed in cognitive functions and impulse control.
    • These disruptions may lead to adverse outcomes in later life.

    Conclusions:

    • Early marijuana use poses significant risks to adolescent neurodevelopment.
    • Further research is crucial to understand and mitigate these risks.
    • Public health initiatives should focus on educating adolescents about marijuana's dangers.