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Morphometric Analyses of Retinal Sections
Published on: February 19, 2012
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Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber
Navid Amini1, Ramin Daneshvar1,2, Farideh Sharifipour1,3
1Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States.
Investigative Ophthalmology & Visual Science
|September 13, 2017
Summary
Peripapillary retinal nerve fiber layer (pRNFL) measurements show stronger structure-function relationships than Bruch's membrane opening-based minimum rim width (BMO-MRW) in glaucoma. Normalizing BMO-MRW did not significantly alter these relationships in the studied eyes.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Optical Coherence Tomography
Background:
- Glaucoma diagnosis and monitoring rely on structure-function (SF) relationships.
- Peripapillary retinal nerve fiber layer (pRNFL) thickness is a common structural measure.
- Bruch's membrane opening-based minimum rim width (BMO-MRW) is an alternative structural measurement.
Purpose of the Study:
- To compare SF relationships between visual fields (VF) and BMO-MRW versus pRNFL in perimetric glaucoma.
- To assess if BMO-MRW can be used across varying glaucoma severities.
- To evaluate the impact of Bruch's membrane opening (BMO) size on BMO-MRW measurements.
Main Methods:
- 108 perimetric glaucoma eyes underwent spectral-domain optical coherence tomography and visual field testing.
- Correlations between global and sectoral BMO-MRW, pRNFL thickness, and VF parameters were analyzed.
- Broken-stick models compared measurement floors for pRNFL and BMO-MRW.
Main Results:
- Spearman correlation coefficients for SF relationships ranged from 0.55 to 0.80 for pRNFL and 0.35 to 0.66 for BMO-MRW.
- BMO-MRW parameters showed weaker SF relationships compared to pRNFL globally and in specific sectors (P < 0.03).
- Normalization of BMO-MRW did not significantly alter SF relationships.
Conclusions:
- SF relationships were weaker with BMO-MRW compared to pRNFL in perimetric glaucoma.
- BMO-MRW normalization did not significantly impact SF relationships in eyes with typical BMO size.
- pRNFL remains a robust structural biomarker for assessing glaucoma progression in relation to visual field defects.
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