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Published on: June 6, 2025
Maximizing donor allocation: A review of UNOS region 9 donor heart turn-downs
Donna Mancini1,2, Daniel Goldstein3, Samantha Taylor4
1Mount Sinai Medical Center, New York, NY, USA.
Insights
Region 9 transplant programs may miss opportunities for heart recovery. Optimizing organ selection practices could increase local heart transplants and save more lives.
Area of Science:
- Transplantation Medicine
- Organ Recovery
- Cardiology
Background:
- Heart transplantation is a critical treatment for end-stage heart failure.
- Organ utilization rates are influenced by transplant center selection practices.
- Region 9 transplant programs' organ selection protocols require evaluation.
Purpose of the Study:
- To assess the optimality of organ selection practices for heart utilization in Region 9.
- To identify potential improvements for increasing local organ recovery rates.
Main Methods:
- Retrospective review of de-identified heart donor data from January 1, 2010, to December 31, 2013.
- Analysis of heart donor utilization, recovery, and reasons for non-transplantation.
- Examination of regional versus out-of-region heart offers and rejections.
Main Results:
- Out of 537 heart donors, 321 (60%) hearts were transplanted.
- 19% (61/321) of hearts were exported after regional turn-downs, with 43 rejected for 'quality' reasons.
- A significant number of rejected hearts were declined by only some regional programs, suggesting potential for increased utilization.
Conclusions:
- Transplant centers in Region 9 may have opportunities to increase local heart recovery by refining organ selection criteria.
- Revisiting donor acceptance protocols could potentially identify additional usable organs without negatively impacting short-term outcomes.
Abstract:
This study was performed to determine if organ selection practices for heart utilization by Region 9 transplant programs were optimal, and to identify opportunities to increase local organ recovery. A retrospective review of de-identified region-wide donor data January 1, 2010 through December 31, 2013 was performed. Over the study period 537 heart donors were identified, of which 321 (60%) were transplanted. Two hundred-sixteen consented hearts were not used; 190 of these were not recovered, and 26 were recovered but not transplanted. Of these, 245/321 (76%) hearts were transplanted at one of 5 regional programs, 15 (5%) were transplanted out of region as primary offers, and 61 (19%) were turned down in region and exported. Of the 61 exported hearts, 43 were turned down in region for donor-related "quality" codes (UNOS 830, 833-837) by at least one program, the remaining 18 hearts were turned down for non-"quality" reasons, primarily histocompatibility and size. Only 5/43 exported were turned down for "quality" reasons by all regional programs offered the organ. A review of consented, not recovered donor offers suggested an additional 28 organs were possibly appropriate for transplant. Our review of regional turn-downs suggests transplant centers could potentially identify additional usable organs without compromising short-term outcomes.
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