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MicroRNAs in the pathogenesis of type 2 diabetes: new research progress and future direction

Chenggui Miao1, Guoxue Zhang2, Zhongwen Xie2

  • 1a Department of Pharmacy, School of Food and Drug, Anhui Science and Technology University, Fengyang 233100, China.

Canadian Journal of Physiology and Pharmacology
|September 13, 2017
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in type 2 diabetes (T2D) pathogenesis and complications. This review explores miRNA

Area of Science:

  • Biochemistry
  • Genetics
  • Endocrinology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • They are crucial in physiological processes and diseases like type 2 diabetes (T2D).
  • T2D involves dysregulated glucose metabolism and is linked to increased complications and mortality, especially in older adults.

Purpose of the Study:

  • To review miRNA-mediated gene modulation in T2D pathogenesis.
  • To explore signaling pathways involved in T2D.
  • To discuss the role of miRNAs in T2D complications and their therapeutic potential.

Main Methods:

  • Literature review of current research on miRNAs and T2D.
  • Analysis of studies on miRNA-mediated gene expression.
  • Synthesis of findings on miRNA's role in T2D complications.

Main Results:

  • miRNAs significantly influence T2D pathogenesis through gene expression modulation.
  • Specific signaling pathways are identified as miRNA targets in T2D.
  • miRNAs play a critical role in the development of various T2D complications.

Conclusions:

  • miRNAs are integral to T2D development and progression.
  • Understanding miRNA roles offers insights into T2D pathophysiology.
  • miRNA-based therapeutics hold promise for T2D treatment.
Keywords:
T2D complicationscomplications du DT2diabète de type 2microRNAnew research progressnouvelle avancée de recherchetherapeutic valuetype 2 diabetesvaleur thérapeutique

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