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Serum paraoxonase activity in patients with ischaemic and nonischaemic dilated cardiomyopathy

Fatih Gungoren1, Tunay Senturk1, Alper Ozturk1

  • 1a Department of Cardiology, Faculty of Medicine , Uludag University , Bursa , Turkey.

Acta Cardiologica
|September 14, 2017
PubMed

Insights

Serum PON1 activity is reduced in patients with dilated cardiomyopathy, both ischemic (IDCM) and non-ischemic (NDCM). Lower PON1 activity in IDCM patients correlates with higher pro-BNP levels, suggesting its diagnostic potential.

Area of Science:

  • Cardiology
  • Biochemistry
  • Biomarkers

Background:

  • Dilated cardiomyopathy (DCM) encompasses both ischemic (IDCM) and non-ischemic (NDCM) forms.
  • Serum paraoxonase 1 (PON1) activity is an indicator of oxidative stress.
  • Pro-brain natriuretic peptide (pro-BNP) is a key biomarker for heart failure.

Purpose of the Study:

  • To investigate differences in serum PON1 activity between IDCM and NDCM patients.
  • To explore the relationship between serum PON1 activity and serum pro-BNP levels in DCM patients.

Main Methods:

  • Echocardiography was used to assess left ventricular ejection fraction (EF < 40%) in 60 patients with heart failure (NYHA class III-IV).
  • Patients were categorized into IDCM and NDCM groups.
  • Serum PON1 activity and pro-BNP levels were measured and compared to 30 healthy controls.

Main Results:

  • Serum PON1 activities were significantly lower in both IDCM and NDCM groups compared to controls.
  • Serum pro-BNP levels were elevated in both IDCM and NDCM groups compared to controls.
  • A significant negative correlation was observed between serum PON1 activity and serum pro-BNP levels in IDCM patients (r = -0.548, p < .001).
  • ROC curve analysis indicated serum PON1 activity could potentially aid in IDCM diagnosis (AUC = 0.798).

Conclusions:

  • Serum PON1 activity is markedly reduced in patients with both IDCM and NDCM.
  • Reduced serum PON1 activity is associated with elevated pro-BNP levels in IDCM, highlighting its potential as a diagnostic biomarker.
Abstract

Keywords:
Serum paraoxonaseheart failureischaemicnonischaemic dilated cardiomyopathy

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