Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

8.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.2K
The Thyroid Gland01:23

The Thyroid Gland

8.0K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
8.0K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.9K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

3.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.4K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

2.1K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
2.1K
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

7.0K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Newly developed diffuse sclerosing papillary thyroid carcinoma during follow-up of benign thyroid nodules: a case report of two cases with ultrasound findings.

Ultrasound international open·2026
Same author

Solitary Fibrous Tumor Arising in Thyroid Follicular Nodular Disease: A Case Report.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026
Same author

Establishment of a prognostic score for distant recurrence in follicular thyroid carcinoma.

Endocrine journal·2026
Same author

<i>DUOXA2</i> Variants as an Underrecognized Cause of Diffuse Goiter: A Euthyroid Adult Case Responsive to Levothyroxine.

Case reports in endocrinology·2026
Same author

Prevalence and Clinical Characteristics of Macro-TSH in Patients with Subclinical Hypothyroidism.

Thyroid : official journal of the American Thyroid Association·2026
Same author

Thyroid hormone measurement items in patients with Hashimoto's thyroiditis on levothyroxine monotherapy: management based on thyroid tissue volume.

Thyroid research·2026

Related Experiment Video

Updated: Feb 23, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.3K

Thyroid Storm: A Japanese Perspective.

Takashi Akamizu1

  • 1The First Department of Medicine, Wakayama Medical University , Wakayama, Japan .

Thyroid : Official Journal of the American Thyroid Association
|September 14, 2017
PubMed
Summary
This summary is machine-generated.

Thyroid storm (TS) is a severe condition with a high mortality rate. This study established new diagnostic criteria and management guidelines for TS in Japan, improving patient care and outcomes.

Keywords:
diagnostic criteriaguidelinemanagementthyroid crisistreatment

More Related Videos

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

1.1K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.6K

Related Experiment Videos

Last Updated: Feb 23, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.3K
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

1.1K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.6K

Area of Science:

  • Endocrinology
  • Critical Care Medicine
  • Public Health

Background:

  • Thyroid storm (TS) is a life-threatening endocrine emergency with poorly defined incidence and management in the early 2000s.
  • Lack of peer-reviewed diagnostic criteria and evidence-based treatment protocols hindered effective patient care.

Purpose of the Study:

  • To develop and validate diagnostic criteria for thyroid storm.
  • To establish evidence-based management and treatment guidelines for thyroid storm.
  • To determine the incidence and mortality rates of thyroid storm in Japan.

Main Methods:

  • Development of initial diagnostic criteria using literature and case data.
  • Nationwide surveys in Japan (2004-2008) to collect and verify TS patient data.
  • Revision of diagnostic criteria and creation of management guidelines based on survey results.

Main Results:

  • Estimated incidence of TS in Japan: 0.20 per 100,000 person-years and 0.22% of thyrotoxic patients.
  • Mortality rate for TS was 10.7%, with multiple organ failure as the leading cause of death.
  • Revised criteria included jaundice (serum bilirubin >3 mg/dL); comprehensive management guidelines and algorithms were developed.

Conclusions:

  • Thyroid storm remains a critical condition with significant mortality.
  • New diagnostic criteria and nationwide data have clarified TS incidence, features, and prognosis.
  • Established guidelines provide a framework for improved TS management and treatment.