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Updated: Feb 23, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
Respiratory support in patients with acute respiratory distress syndrome: an expert opinion
Davide Chiumello1, Laurent Brochard2,3, John J Marini4
1Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy.
Abstract:
Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality rates of around 30-45% and considerable long-term morbidity. Respiratory support in these patients must be optimized to ensure adequate gas exchange while minimizing the risks of ventilator-induced lung injury. The aim of this expert opinion document is to review the available clinical evidence related to ventilator support and adjuvant therapies in order to provide evidence-based and experience-based clinical recommendations for the management of patients with ARDS.
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