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The evolutionary logic of sepsis.

Lajos Rózsa1, Péter Apari2, Mihály Sulyok3

  • 1MTA-ELTE-MTM Ecology Research Group, Budapest, Pázmány P. s. 1/C, H-1117, Hungary; Evolutionary Systems Research Group, MTA Centre for Ecological Research, Tihany, Hungary.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|September 14, 2017
PubMed
Summary

The human microbiome may intentionally cause sepsis to spread after death. This "Microbiome Mutiny Hypothesis" suggests microbes switch strategies for transmission, offering new sepsis treatment possibilities.

Keywords:
Cadaver-borne transmissionEvolutionary medicineFacultative virulenceMicrobiome Mutiny HypothesisSepsis

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Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Infectious Diseases

Background:

  • The Microbiome Mutiny Hypothesis suggests microbes exploit hosts when health declines.
  • Sepsis, a systemic reaction to microbial invasion, is a leading cause of death.
  • Current understanding doesn't fully explain how sepsis-causing microbes transmit.

Purpose of the Study:

  • To propose that sepsis induction by certain microbiome members is an adaptive evolution.
  • To suggest sepsis can be a strategy for microbes to colonize cadavers and spread.
  • To hypothesize a microbial life cycle involving mutualism, pathogenesis, decomposition, and re-emergence.

Main Methods:

  • Theoretical proposal based on existing knowledge of microbiome and sepsis.
  • Hypothesizing adaptive evolution for sepsis-inducing microbes.
  • Predicting testable scenarios for microbial behavior and transmission.

Main Results:

  • Sepsis induction may be an adaptive strategy for microbiome members.
  • Microbes capable of causing sepsis might also decompose cadavers.
  • This suggests a potential 'mutualist - pathogen - decomposer' microbial life cycle.

Conclusions:

  • Certain sepsis cases might result from facultative phenotypic switching of microbiome members.
  • This microbial plasticity could be a novel factor in sepsis etiology.
  • Confirming this hypothesis could lead to new sepsis prevention and treatment strategies.