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Updated: Feb 23, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Is PET/CT essential in the diagnosis and follow-up of temporal arteritis?
Carlo Salvarani1, Alessandra Soriano2, Francesco Muratore1
1Division of Rheumatology, Azienda USL - Istituto di Ricovero e Cura a Carattere Scientifico di Reggio Emilia, Viale Risorgimento 80, 42100 Reggio Emilia, Italy; Modena and Reggio Emilia University, Via Università 4, 41121 Modena, Italy.
Abstract:
The increasing availability and improvement of imaging techniques are deeply influencing diagnosis and work-up of patients affected with vasculitis, particularly those with large vessel vasculitis (LVV). Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET), especially when integrated with computed tomography (CT), is taking hold as a useful diagnostic technique to examine the aorta and the other large vessels in giant cell arteritis (GCA) with concomitant large vessel involvement (LV-GCA). In this paper we examined the progresses performed in this field in the last twenty years and the evidence available so far according to two different points of view ('pros' and 'cons'), in order to give a comprehensive answer to a still open question about the role of PET/CT in the diagnosis and follow-up of GCA.
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