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Three-Dimensional Particle Shape Analysis Using X-ray Computed Tomography: Experimental Procedure and Analysis Algorithms for Metal Powders
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Estimation of Drug Particle Size in Intact Tablets by 2-Dimensional X-Ray Diffractometry

Seema Thakral1, Naveen K Thakral2, Raj Suryanarayanan2

  • 1Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455; Characterization Facility, University of Minnesota, Minneapolis, Minnesota 55455.

Journal of Pharmaceutical Sciences
|September 14, 2017
PubMed
Summary

This study validates using 2D X-ray diffraction to measure grain size in organic powders and intact tablets. The method accurately determined acetaminophen grain size in marketed formulations, showing its pharmaceutical utility.

Keywords:
X-ray diffractioncompressiondissolutionparticle sizepowderstablets

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