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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
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X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
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X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

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X-ray data processing.

Harold R Powell1

  • 1Harry Powell Crystallographic, Buxton Road, Chingford, London E4 7DP, U.K. hrp1000@virginmedia.com.

Bioscience Reports
|September 14, 2017
PubMed
Summary
This summary is machine-generated.

X-ray crystallography, a century-old technique for molecular structure determination, has evolved with advancements in X-ray sources and detectors. This review covers essential processes like autoindexing and data integration using common software.

Keywords:
crystallographydata processingsoftware

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Area of Science:

  • Crystallography
  • Structural Biology
  • Biophysics

Background:

  • X-ray crystallography has been pivotal in determining molecular structures for over 100 years.
  • Significant advancements in X-ray sources and detector technology have driven progress in the field.

Observation:

  • The process involves measuring diffraction patterns using area detectors.
  • Key steps include autoindexing, refining crystal and detector parameters, and integrating reflection data.

Findings:

  • The discussion highlights fundamental processes in diffraction data collection and scaling.
  • Emphasis is placed on commonly utilized software packages in X-ray crystallography.

Implications:

  • Understanding these fundamental processes is crucial for accurate molecular structure determination.
  • The review provides insights into the practical application of X-ray crystallography in scientific research.