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Calcium fluoride based multifunctional nanoparticles for multimodal imaging.

Marion Straßer1,2, Joachim H X Schrauth3,4, Sofia Dembski1,5,6

  • 1Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, 97082 Wuerzburg, Germany.

Beilstein Journal of Nanotechnology
|September 14, 2017
PubMed
Summary

New multifunctional nanoparticles (NPs) combining photoluminescence and magnetic resonance imaging capabilities were synthesized. These novel contrast agents show promise for advanced medical diagnostics and regenerative medicine applications with no observed cytotoxicity.

Keywords:
calcium fluoride nanoparticlesmagnetic resonance imaging (MRI)multifunctional nanoparticlesmultimodal imagingphotoluminescence

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Imaging

Background:

  • Multifunctional nanoparticles (NPs) offer advanced capabilities for medical imaging.
  • Integrating photoluminescence (PL) and magnetic resonance imaging (MRI) modalities enhances diagnostic potential.

Purpose of the Study:

  • To synthesize and characterize novel CaF2:(Tb3+, Gd3+) NPs.
  • To evaluate their suitability as dual-modal contrast agents (CAs) for PL and MRI.
  • To assess their safety and stability for medical applications.

Main Methods:

  • Wet-chemical synthesis of spherical NPs (5-10 nm diameter).
  • Characterization of crystalline structure and doping with Tb3+ and Gd3+ ions.
  • Evaluation of MRI relaxivity and cytotoxicity in human dermal fibroblasts.

Main Results:

  • Synthesized NPs exhibit paramagnetism and fluorescence.
  • NPs function as effective MRI CAs with a mean relaxivity of 0.471 mL·mg-1·s-1.
  • No cytotoxicity observed at concentrations up to 1 mg·mL-1 after 24h exposure.

Conclusions:

  • CaF2:(Tb3+, Gd3+) NPs are reproducible and stable dual-modal imaging agents.
  • These NPs demonstrate significant potential for diagnostics and tissue characterization in regenerative medicine.
  • The developed NPs are safe and effective for advanced medical imaging.