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Related Experiment Video

Updated: Feb 23, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

Tim-3, Lag-3, and TIGIT.

Nicole Joller¹, Vijay K Kuchroo²

¹Institute for Experimental Immunology, University of Zurich, Zurich, Switzerland.

Current Topics in Microbiology and Immunology

|September 14, 2017

Summary

This summary is machine-generated.

Co-inhibitory receptors like Tim-3, Lag-3, and TIGIT regulate T cell function. Understanding their roles is crucial for managing autoimmunity and enhancing antitumor responses.

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Area of Science:

Immunology
Cellular Biology
Molecular Medicine

Background:

Co-inhibitory receptors are critical regulators of T cell responses and immune homeostasis.
While preventing autoimmunity, these receptors can limit anti-tumor and anti-pathogen immunity.
T cells express a diverse array of co-inhibitory receptors with varied functions.

Purpose of the Study:

To examine the function of Tim-3, Lag-3, and TIGIT in T cell regulation.
To investigate their roles in maintaining self-tolerance and peripheral T cell responses.
To explore their synergistic effects in autoimmunity and anti-tumor immunity.

Main Methods:

Focus on the co-inhibitory receptors Tim-3, Lag-3, and TIGIT.
Analysis of T cell function and regulation.
Investigation of immune homeostasis and self-tolerance mechanisms.

Main Results:

Tim-3, Lag-3, and TIGIT significantly influence T cell function.
These receptors play a role in peripheral tissue immune responses.
Synergistic actions of these receptors impact autoimmunity and anti-tumor immunity.

Conclusions:

Co-inhibitory receptors Tim-3, Lag-3, and TIGIT are key modulators of T cell-mediated immunity.
Targeting these receptors may offer therapeutic strategies for autoimmune diseases and cancer.
Further research into their complex interactions is warranted for immune-based therapies.