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Related Experiment Video

Updated: Feb 23, 2026

Micro-scale Engineering for Cell Biology
04:42

Micro-scale Engineering for Cell Biology

Published on: October 1, 2007

5.3K

Introduction.

Alexei V Tepikin1

  • 1The Physiological Laboratory, Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK. A.Tepikin@liverpool.ac.uk.

Advances in Experimental Medicine and Biology
|September 14, 2017
PubMed
Summary

Store-operated calcium entry (SOCE) is a vital cellular process involving complex interactions between cellular compartments. Misregulation of SOCE contributes to various pathologies, highlighting its critical biological role.

Keywords:
Ca2+ influxCa2+ signalingER-PM junctionsMembrane contact sitesOrganelle contact sitesStore-operated Ca2+ entry

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Last Updated: Feb 23, 2026

Micro-scale Engineering for Cell Biology
04:42

Micro-scale Engineering for Cell Biology

Published on: October 1, 2007

5.3K

Area of Science:

  • Cellular Biology
  • Molecular Physiology

Background:

  • Store-operated calcium entry (SOCE) is a fundamental signaling pathway utilizing calcium ions (Ca2+).
  • SOCE is crucial for the function of diverse cell and tissue types.
  • Dysregulation of SOCE is implicated in significant pathological conditions.

Purpose of the Study:

  • To explore the intricate mechanisms underlying SOCE.
  • To elucidate the cross-talk between cellular compartments in SOCE.
  • To emphasize the importance and complexity of SOCE signaling.

Main Methods:

  • The study reviews existing literature on SOCE.
  • It analyzes the role of organelle and cellular compartments in SOCE.
  • It discusses the signaling modality and physiological relevance of SOCE.

Main Results:

  • SOCE involves complex interactions ('cross-talk') among cellular compartments.
  • Specific downstream signaling events are dependent on SOCE, not just global calcium increases.
  • SOCE is essential for normal cellular function and its misregulation causes disease.

Conclusions:

  • The 'tail' of SOCE is complex, involving multiple cellular 'dogs' or compartments.
  • SOCE's specific signaling modality and vital role justify its significance.
  • Understanding SOCE is critical for both basic science and understanding disease.