Effect on Morphology, Osmotic Fragility and Electro Kinetic Potential of Erythrocytes in Hypertension

Area of Science:

• Biomedical science
• Cardiovascular research
• Hematology

Background:

• Hypertension is a prevalent global health issue and a major risk factor for cardiovascular disease (CVD).
• Early identification of individuals at risk for CVD is crucial for timely intervention and management.

Purpose of the Study:

• To evaluate the erythrocyte zeta potential (ZP) as an additional biomarker for cardiovascular disorder risk.
• To assess if ZP can facilitate earlier detection and treatment of patients susceptible to cardiovascular disease.

Main Methods:

• Blood samples were collected from hypertensive patients and healthy volunteers.
• Erythrocyte zeta potential was measured using a Zeta meter and video tracking software.
• Data were recorded multiple times per sample to ensure accuracy of average ZP measurements.

Main Results:

• Mean ZP in healthy controls was 23.41 mV, significantly higher than in hypertensive patients (16.05 mV).
• Hypertensive patients with diabetes exhibited even lower ZP values (6.96-22.76 mV) and showed erythrocyte structural deformities and increased osmotic fragility.
• A significantly lower ZP was observed in hypertensive patients compared to healthy individuals.

Conclusions:

• Reduced erythrocyte zeta potential, alongside morphological changes and increased osmotic fragility, may contribute to cardiovascular disease progression.
• Erythrocyte zeta potential shows promise as an additional indicator for identifying individuals at risk of cardiovascular disorders.
• This research highlights the potential of ZP measurement for improved cardiovascular risk assessment.