Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

2.0K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.0K
Plasticity00:58

Plasticity

3.2K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.2K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.8K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.8K
Plastic Deformations01:19

Plastic Deformations

504
Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
504
Long-term Potentiation01:25

Long-term Potentiation

3.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.7K
Long-term Potentiation01:35

Long-term Potentiation

58.9K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
58.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Game-Based Assessment of Spatial Cognition Across a Wide Age Range.

Behavioral sciences (Basel, Switzerland)·2026
Same author

An Investigation of Hand Use in Preschool Children: Vocabulary and Social Competence Predict Cognitive Development.

Journal of child language·2025
Same author

Tactile stimulation facilitates functional recovery and dendritic change following neonatal hemidecortication in rats.

Behavioural brain research·2023
Same author

Acute gut inflammation reduces neural activity and spine maturity in hippocampus but not basolateral amygdala.

Scientific reports·2022
Same author

Comparison of motor recovery after neonatal and adult hemidecortication.

Behavioural brain research·2022
Same author

Tactile stimulation improves cognition, motor, and anxiety-like behaviors and attenuates the Alzheimer's disease pathology in adult APP<sup>NL-G-F/NL-G-F</sup> mice.

Synapse (New York, N.Y.)·2022
Same journal

Predictive ability of the Hammersmith Neonatal Neurological Examination for identifying severe neurodevelopmental impairment in infants born very preterm.

Developmental medicine and child neurology·2026
Same journal

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management.

Developmental medicine and child neurology·2026
Same journal

Hammersmith Infant Neurological Examination global scores for predicting neurodevelopmental outcomes after 2 years of age: A systematic review and meta-analysis.

Developmental medicine and child neurology·2026
Same journal

Seizure worsening and sodium channel blockers in HCN1-related epilepsies: A case series.

Developmental medicine and child neurology·2026
Same journal

What is the impact of childhood-onset disability research - and what should it be?

Developmental medicine and child neurology·2026
Same journal

Sleep disturbances in children with cerebral palsy, their siblings, and parents: A qualitative descriptive study.

Developmental medicine and child neurology·2026
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

7.4K

Principles of plasticity in the developing brain.

Bryan Kolb1,2, Allonna Harker1, Robbin Gibb1

  • 1Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.

Developmental Medicine and Child Neurology
|September 14, 2017
PubMed
Summary
This summary is machine-generated.

The developing brain

More Related Videos

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

16.4K
A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

13.3K

Related Experiment Videos

Last Updated: Feb 23, 2026

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

7.4K
Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

16.4K
A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

13.3K

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Behavioral Biology

Background:

  • The developing brain exhibits significant plasticity, influenced by experiences.
  • This plasticity shapes lifelong behavioral outcomes.
  • Metaplasticity describes the interaction of life experiences.

Purpose of the Study:

  • To review principles regulating brain plasticity during development.
  • To identify factors modulating the developing brain.
  • To emphasize changes in behavior, epigenetics, and neuronal morphology.

Main Methods:

  • Literature review of developmental neuroscience.
  • Analysis of factors influencing brain development.
  • Focus on behavioral, epigenetic, and morphological changes.

Main Results:

  • Early life experiences profoundly impact brain development and behavior.
  • A wide array of factors modulate brain plasticity.
  • Interacting life experiences lead to metaplasticity.

Conclusions:

  • Brain development is sensitive to diverse environmental and biological factors.
  • Understanding these factors is crucial for predicting behavioral outcomes.
  • Epigenetic and morphological changes underlie experience-dependent plasticity.