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Somatostatin: peripheral venoconstrictive activity and interaction with monoamines in man
A Panconesi1, P L Del Bianco, G Franchi
1Institute of Internal Medicine and Clinical Pharmacology, University of Florence, Italy.
Regulatory Peptides
|September 1, 1987
Summary
The study investigated how somatostatin constricts veins and causes tachyphylaxis in human hand veins. Somatostatin potentiates some vasoactive monoamines but does not show cross-tachyphylaxis with them.
Area of Science:
- Pharmacology
- Physiology
- Vascular Biology
Background:
- Somatostatin is a peptide hormone with diverse physiological roles.
- Its effects on vascular tone, specifically venoconstriction, are not fully understood.
- Tachyphylaxis, a rapid decrease in drug response, is a key aspect to investigate.
Purpose of the Study:
- To investigate the mechanism of somatostatin-induced venoconstriction in the human hand vein.
- To examine the phenomenon of tachyphylaxis with somatostatin in this vascular bed.
- To explore potential interactions between somatostatin and other vasoactive monoamines.
Main Methods:
- In vivo investigation of human hand vein responses.
- Assessment of venoconstriction induced by somatostatin and various vasoactive monoamines (5-hydroxytryptamine, noradrenaline, adrenaline, dopamine, tyramine).
- Evaluation of cross-tachyphylaxis between somatostatin and other agents.
- Pharmacological antagonism studies using phentolamine, methysergide, haloperidol, and morphine.
Main Results:
- No cross-tachyphylaxis was observed between somatostatin and 5-hydroxytryptamine, noradrenaline, adrenaline, dopamine, or tyramine.
- Somatostatin potentiated the venoconstrictive effects of noradrenaline, adrenaline, and dopamine.
- Somatostatin did not potentiate the venoconstrictive effects of 5-hydroxytryptamine and tyramine.
- Phentolamine antagonized somatostatin-induced venoconstriction.
- Methysergide, haloperidol, and morphine did not antagonize somatostatin-induced venoconstriction.
Conclusions:
- Somatostatin induces venoconstriction in the human hand vein.
- The mechanism of somatostatin venoconstriction does not involve cross-tachyphylaxis with common vasoactive monoamines.
- Somatostatin may interact with specific receptors, potentially alpha-adrenergic, in the hand vein.
- The precise mechanism of somatostatin venoconstriction and its interaction with vasoactive monoamines requires further elucidation.