Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation
Naglaa A Abdel Hafez1, Huwaida M E Hassaneen2, Thoraya A Farghaly2,3
1Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo, Egypt.
Mini Reviews in Medicinal Chemistry
|September 14, 2017
Abstract
Objective And Background:
Hydrazonoyl halides were used as precursors for the synthesis of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.
Conclusion:
The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f showed promising activity.
