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Advances in paediatric gastroenterology

Paul K H Tam1, Patrick H Y Chung1, Shawn D St Peter2

  • 1Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

Lancet (London, England)
|September 14, 2017
PubMed

Insights

Minimally invasive surgery shows promise in pediatric gastrointestinal surgery, especially for common conditions. Further research is needed for rare neonatal disorders and long-term care for survivors.

Area of Science:

  • Pediatric Surgery
  • Gastrointestinal Surgery
  • Neonatal Surgery

Background:

  • Minimally invasive surgery (MIS) is advancing in pediatric gastrointestinal surgery.
  • MIS benefits are well-established for common conditions like appendicitis.
  • Challenges exist in applying MIS to rare neonatal gastrointestinal disorders due to limited clinical trial data.

Purpose of the Study:

  • To review recent developments in pediatric gastrointestinal surgery.
  • To highlight the need for clinical evidence in rare neonatal conditions.
  • To discuss future research directions, including genetics and stem-cell therapy.

Main Methods:

  • Review of current literature on pediatric and neonatal gastrointestinal surgery.
  • Analysis of evidence supporting minimally invasive approaches.
  • Discussion of challenges and future research needs for rare diseases.

Main Results:

  • Minimally invasive surgery is supported by strong evidence for common pediatric gastrointestinal issues.
  • Clinical trials for rare neonatal disorders are difficult but crucial.
  • Specialization and collaboration have improved outcomes for conditions like biliary atresia.

Conclusions:

  • High-quality evidence is essential for advancing pediatric and neonatal gastrointestinal surgery.
  • Future research should focus on rare diseases, long-term sequelae, and underlying pathogenesis.
  • Genetics and stem-cell therapy offer potential for conditions like Hirschsprung's disease.

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