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Avoiding nerve stimulation in irreversible electroporation: a numerical modeling study.

Borja Mercadal¹, Christopher B Arena², Rafael V Davalos²

¹Department of Information and Communication Technologies, Universitat Pompeu Fabra, Roc Boronat, 138, 08018 Barcelona, Spain.

Physics in Medicine and Biology

|September 14, 2017

Summary

This summary is machine-generated.

Replacing long monopolar pulses with short bipolar pulses in electroporation treatments can ablate tissue without stimulating nerves. This novel approach enhances treatment safety by leveraging different electrical thresholds for electroporation and nerve stimulation.

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Area of Science:

Biomedical Engineering
Electrophysiology
Medical Physics

Background:

Electroporation treatments use high-voltage pulses, which can undesirably stimulate excitable tissues like nerves and muscles.
This electrical stimulation complicates treatments and poses risks to patients.
Minimizing nerve stimulation is crucial for improving the safety and efficacy of electroporation therapies.

Purpose of the Study:

To numerically analyze the effectiveness of using bursts of short bipolar pulses instead of monopolar pulses to reduce nerve stimulation during electroporation.
To compare different pulsing protocols regarding their electroporation efficacy and nerve action potential triggering.
To provide a scientific rationale for employing bipolar pulses in electroporation-based treatments.

Main Methods:

Developed a computational modeling framework integrating numerical models of nerve fibers.
Incorporated experimental data on irreversible electroporation into the modeling framework.
Compared the electroporation efficacy and nerve stimulation potential of monopolar and bipolar pulsing protocols.

Main Results:

Bursts of short bipolar pulses can achieve tissue ablation without triggering action potentials in nearby nerves.
Reduced pulse length in bipolar pulses increases stimulation thresholds faster than irreversible electroporation thresholds.
Nerve fibers exhibit slower transmembrane charging compared to electroporation-treated cells due to geometrical differences, explaining the observed threshold disparities.

Conclusions:

Replacing conventional monopolar pulses with bursts of short bipolar pulses is a viable strategy to enhance electroporation treatment safety.
The distinct pulse length dependencies of stimulation and electroporation thresholds allow for targeted tissue ablation while sparing nerves.
This approach offers a promising method for complex electroporation-based therapies involving proximity to excitable tissues.