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Related Experiment Video

Updated: Feb 23, 2026

Iris Fixation via External Pentagram Suturing
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Posterior Amorphous Corneal Dystrophy Associated With Keratoglobus: A Case Report.

Jonathan Fay1, Alexandra A Herzlich, George J Florakis

  • 1*Columbia University, New York, NY; and †Department of Ophthalmology, Albert Einstein College of Medicine, New York, NY.

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Summary

Posterior amorphous corneal dystrophy (PACD) is a rare condition. This case study details a patient with PACD who developed progressive corneal ectasia, a condition not previously associated with PACD.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Corneal Diseases

Background:

  • Posterior amorphous corneal dystrophy (PACD) is a rare, non-progressive corneal dystrophy.
  • PACD is characterized by posterior stromal opacification, corneal thinning, and decreased curvature.
  • PACD is not typically associated with corneal ectasia.

Observation:

  • A single patient with PACD was monitored from birth to age 15.
  • The patient presented with bilateral cloudy corneas at birth.
  • Exclusion of congenital infection, metabolic disease, and glaucoma was performed.

Findings:

  • Anterior segment OCT confirmed posterior stromal opacification consistent with PACD.
  • Corneal thinning progressed significantly in both eyes.
  • Progressive steepening of corneal curvature, indicative of ectasia, was observed.

Implications:

  • This case highlights a potential association between PACD and progressive corneal ectasia.
  • Further research is needed to understand the underlying mechanisms and potential collagen abnormalities.
  • This finding may influence the long-term management of patients with PACD.