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Updated: Feb 23, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

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MicroRNAs as Biomarkers in Colorectal Cancer

Takaaki Masuda1, Naoki Hayashi2, Yosuke Kuroda3

  • 1Department of Surgery, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu 874-0838, Japan. takaaki.masuda.280@m.kyushu-u.ac.jp.

Cancers
|September 14, 2017
PubMed

Insights

MicroRNAs (miRs) are promising biomarkers for colorectal cancer (CRC) detection and prognosis. Aberrant miR expression is linked to CRC development, offering potential for early diagnosis and treatment strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • MicroRNAs (miRs) are small non-coding RNAs regulating gene expression.
  • Aberrant miR expression is implicated in various cancers, including colorectal cancer (CRC).
  • miRs show potential as biomarkers due to their stability and tissue specificity.

Purpose of the Study:

  • To review the role of miRs as biomarkers in colorectal cancer (CRC).
  • To assess the diagnostic, prognostic, and predictive potential of miRs in CRC.
  • To discuss current challenges in the clinical application of miRs for CRC.

Main Methods:

  • Systematic review of meta-analyses and large-scale studies.
  • Focus on studies with strong statistical confidence.
  • Analysis of miR expression patterns in CRC development.

Main Results:

  • miRs are significantly altered in colorectal cancer (CRC) tissues.
  • Specific miRs demonstrate potential as diagnostic and prognostic markers for CRC.
  • miRs can predict treatment response in CRC patients.

Conclusions:

  • miRs hold significant promise as biomarkers for colorectal cancer (CRC).
  • Further research and standardization are needed for clinical implementation.
  • miRs could improve CRC early detection, prognosis, and personalized treatment.
Keywords:
biomarkercolorectal cancermicroRNA

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