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Related Experiment Video

Updated: Feb 23, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Molecular engineering solutions for therapeutic peptide delivery.

Handan Acar¹, Jeffrey M Ting, Samanvaya Srivastava

¹Institute for Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA. mtirrell@uchicago.edu.

Chemical Society Reviews

|September 14, 2017

Summary

Therapeutic peptides offer targeted protein interaction modulation for personalized medicine. Nanoparticle engineering enhances peptide delivery, overcoming biological barriers for improved clinical translation.

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Area of Science:

Biochemistry and Molecular Biology
Nanotechnology
Pharmacology

Background:

Protein-protein interactions are crucial for cellular function and homeostasis.
Dysregulation of these interactions can lead to various diseases.
Therapeutic peptides, short amino acid sequences, can modulate these interactions.

Purpose of the Study:

To review the potential of therapeutic peptides as personalized medicines.
To discuss the challenges limiting the clinical translation of therapeutic peptides.
To highlight advances in nanoparticle engineering for peptide delivery.

Main Methods:

Review of current literature on therapeutic peptides and nanoparticle delivery systems.
Focus on self-assembled nanocarriers for peptide protection and targeted delivery.
Analysis of molecular and chemical engineering strategies.

Main Results:

Therapeutic peptides demonstrate high selectivity, safety, and biocompatibility.
In vivo pharmacokinetic barriers impede peptide clinical translation.
Nanoparticle engineering offers solutions to protect peptides and enhance tissue delivery.

Conclusions:

Self-assembled nanoparticles represent a promising strategy for overcoming peptide delivery challenges.
Advances in engineering are crucial for realizing the full therapeutic potential of peptides.
Peptide-based therapeutics, enabled by nanocarriers, are poised to advance personalized medicine.