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Related Concept Videos

Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Liver Histology01:27

Liver Histology

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
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Hepatic Portal System01:21

Hepatic Portal System

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
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Related Experiment Video

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Steps for the Autologous Ex vivo Perfused Porcine Liver-kidney Experiment
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Steps for the Autologous Ex vivo Perfused Porcine Liver-kidney Experiment

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[Organinteraction between liver and kidney].

Kevin Roedl, Dominik Jarczak, Valentin Fuhrmann

    Deutsche Medizinische Wochenschrift (1946)
    |September 14, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Kidney function alterations are common in liver disease patients, often leading to acute kidney injury. This review details the critical clinical interactions between the kidneys and liver.

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    In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

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    Area of Science:

    • Nephrology
    • Hepatology
    • Internal Medicine

    Background:

    • Liver diseases frequently impact kidney function.
    • Multiple mechanisms contribute to renal dysfunction in hepatic conditions.
    • Acute kidney injury is a common complication in patients with acute or chronic liver disease.

    Purpose of the Study:

    • To review the significant clinical interactions between the kidneys and liver.
    • To elucidate the mechanisms underlying kidney function alterations in liver disease.
    • To provide an overview of acute kidney injury in the context of hepatic pathology.

    Main Methods:

    • Literature review of clinical studies and case reports.
    • Analysis of pathophysiological mechanisms.
    • Synthesis of current understanding on kidney-liver interactions.

    Main Results:

    • Established link between liver disease severity and renal impairment.
    • Identified key pathways contributing to hepatorenal syndrome.
    • Highlighted the diagnostic challenges and therapeutic implications of acute kidney injury in liver disease.

    Conclusions:

    • Kidney function monitoring is crucial for patients with liver disease.
    • Understanding the interplay between liver and kidney is vital for patient management.
    • Further research is needed to improve outcomes for patients with co-existing liver and kidney conditions.