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Biodegradable Viral Nanoparticle/Polymer Implants Prepared via Melt-Processing.

Parker W Lee1, Sourabh Shukla1, Jaqueline D Wallat1

  • 1Department of Macromolecular Science and Engineering, Case School of Engineering, ‡Department of Biomedical Engineering, Case School of Engineering, §School of Medicine, and ∥Case Comprehensive Cancer Center, Division of General Medical Sciences-Oncology, Case Western Reserve University , Cleveland, Ohio 44106, United States.

ACS Nano
|September 14, 2017
PubMed
Summary

Melt-encapsulation successfully created viral nanoparticle-laden polymeric materials for sustained vaccine delivery. This novel method enables effective in vivo particle delivery and immune response with potentially fewer administrations.

Keywords:
PLGAPeclet numbermelt-processingsingle administration vaccinevaccinationviral nanoparticle

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Area of Science:

  • Biomaterials Science
  • Vaccine Technology
  • Nanotechnology

Background:

  • Viral nanoparticles are versatile platforms for vaccine development.
  • Current vaccine delivery often requires multiple injections, impacting patient compliance.
  • Sustained release systems are needed to improve vaccine administration efficacy.

Purpose of the Study:

  • To develop a single-dose vaccine delivery system using viral nanoparticles.
  • To investigate melt-encapsulation as a method for creating these materials.
  • To assess the integrity, release profile, and immunogenicity of viral nanoparticles within polymeric matrices.

Main Methods:

  • Fabrication of viral nanoparticle-laden polymeric materials via melt-encapsulation.
  • Analysis of particle integrity, aggregation, and dispersion within the polymer matrix.
  • In vivo studies to evaluate antibody generation and immune response.

Main Results:

  • Melt-encapsulation effectively produced composite materials delivering intact viral nanoparticles.
  • Processing parameters were established to control particle integrity and aggregation.
  • The materials demonstrated sustained release of viral nanoparticles, eliciting a comparable immune response to traditional methods.

Conclusions:

  • Melt-encapsulation is a viable, solvent-free technique for producing sustained-release viral nanoparticle vaccines.
  • This approach offers potential for improved patient compliance through reduced dosing frequency.
  • Further development can lead to more complex vaccine formulations with enhanced therapeutic potential.