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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Interlinked bistable mechanisms generate robust mitotic transitions.

Lukas H Hutter1,2, Scott Rata1, Helfrid Hochegger3

  • 1a Department of Biochemistry , University of Oxford , Oxford , UK.

Cell Cycle (Georgetown, Tex.)
|September 14, 2017
PubMed
Summary
This summary is machine-generated.

Cell cycle transitions rely on robust, switch-like mechanisms. New mathematical models reveal that two interlinked bistable switches enhance the cell cycle

Keywords:
Aurora BCDK1GreatwallPP2A:B55biochemical switchescancer cellscheckpoint controlcyclinserror correctionmitosisspindle assembly checkpoint

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Area of Science:

  • Cell Biology
  • Systems Biology
  • Biochemistry

Background:

  • Cell cycle phase transitions are critical for accurate DNA replication and cell division.
  • Robust and switch-like transitions ensure temporal separation of key cell cycle events.
  • Mathematical models suggest bistable switches underlie these cell cycle properties.

Purpose of the Study:

  • To present new mathematical models for cell cycle control systems.
  • To analyze regulatory motifs governing mitotic entry/exit and the mitotic checkpoint.
  • To investigate how interlinked bistable switches enhance transition robustness and irreversibility.

Main Methods:

  • Development of novel mathematical models for cell cycle regulatory networks.
  • Analysis of qualitative features of two interlinked bistable switch motifs.
  • Comparison of mutually activating (mitotic checkpoint) and mutually inhibiting (mitotic entry/exit) switch dynamics.

Main Results:

  • Each control system features two interlinked bistable switches.
  • Mutually activating switches characterize mitotic checkpoint control.
  • Mutually inhibiting switches characterize mitotic entry/exit networks, enhancing robustness and irreversibility.

Conclusions:

  • Interlinked bistable switches provide enhanced robustness and irreversibility to cell cycle transitions.
  • These network motifs may govern other critical cellular transitions between biochemical states.
  • The findings offer insights into the fundamental mechanisms of cell cycle regulation.