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The mumps-specific T cell response in healthy individuals and insulin-dependent diabetics: preferential restriction

O Bruserud1, G Paulsen, E Thorsby

  • 1Institute of Transplantation Immunology, University of Oslo, Norway.

Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology
|August 1, 1987
PubMed

Insights

Mumps-specific T cells in DR4 heterozygotes are preferentially restricted by Dw4 or Dw14 elements on DR4 molecules. This finding clarifies T-cell restriction in immune responses to mumps virus.

Area of Science:

  • Immunology
  • Human Genetics

Background:

  • Previous studies identified increased mumps-specific T lymphocytes restricted by Human Leukocyte Antigen (HLA)-DR4-associated elements in DR4 heterozygotes.
  • The specific DR4 subtypes responsible for this preferential restriction were not fully elucidated.

Purpose of the Study:

  • To investigate the specific DR4 subtypes that preferentially restrict mumps-specific T lymphocytes in DR4 heterozygotes.
  • To determine if genomic DQ-beta-polymorphism is associated with this preferential restriction.

Main Methods:

  • Analysis of T-lymphocyte restriction elements in DR4 heterozygotes.
  • Subtyping of DR4 molecules, including Dw4 and Dw14.
  • Examination of genomic DQ-beta-polymorphism.

Main Results:

  • The preferential restriction of mumps-specific T lymphocytes was found to be associated with DR4 molecules expressing either Dw4 or Dw14 subtypes.
  • No association was observed between preferential restriction elements and specific genomic DQ-beta-polymorphisms.

Conclusions:

  • Specific DR4 subtypes, namely Dw4 and Dw14, play a key role in the preferential restriction of mumps-specific T lymphocytes.
  • Immune response modulation by specific HLA alleles is further clarified, with no apparent influence from DQ-beta-polymorphism in this context.

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