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Hyperin protects against cisplatin-induced liver injury in mice
Chengwei Niu1, Man Ma2, Xiao Han3
1PhD, College of Pharmacy, Jiangsu Food and Pharmaceutical Science College, China. Conception, design, intellectual and scientific content of the study; acquisition, analysis and interpretation of data; technical procedures; statistical analysis; manuscript preparation and writing; critical revision.
Purpose::
To evaluate the effect of hyperin in cisplatin-induced liver injury in mice.
Methods::
Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was administrated one hour after the final intragastrication of hyperin. Twenty-four hours later, blood and liver were collected for further research.
Results::
A single injection of cisplatin (40 mg/kg) for 24 h significantly increased serum alanine and aspartate aminotransferases (ALT/AST) and gamma glutamyl transferase (GGT) activities, whileas hyperin reversed cisplatin-induced such increases. Liver histopathological examination further demonstrated the protection of hyperin against cisplatin-induced liver injury. Further results showed hyperin reversed cisplatin-induced the increase in content of malondialdehyde (MDA) and the decrease in level of total antioxidant capacity (T-AOC) in liver. Moreover, hyperin increased the levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), glutathione-s transferase (GST) in cisplatin-induced liver.
Conclusion::
Hyperin inhibits cisplatin-induced hepatic oxidative stress, which contributes greatly to the amelioration of cisplatin-induced liver injury in mice.
