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Linkage of DNA probe B79a (D7S13) to cystic fibrosis
B J Wainwright1, L C Tsui, M Leppert
1Department of Biochemistry, St. Mary's Hospital Medical School, University of London, England.
American Journal of Human Genetics
|November 1, 1987
Abstract:
We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at theta = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.