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Beta-adrenergic blockers decrease levels of luteinizing hormone in plasma of orchidectomized rats.

S L Petrovic1, J C Bedran de Castro, S M McCann

  • 1Department of Physiology, University of Texas Health Science Center, Dallas 75235.

Biology of Reproduction
|October 1, 1987
PubMed
Summary
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Beta-adrenergic antagonists like propranolol significantly lowered luteinizing hormone (LH) in rats. This suggests beta-blockers may reduce LH release at the pituitary level.

Area of Science:

  • Endocrinology
  • Neuropharmacology

Background:

  • Beta-adrenergic receptors play a role in regulating hormone release.
  • Luteinizing hormone (LH) is crucial for reproductive functions.

Purpose of the Study:

  • To investigate the effect of beta-adrenergic antagonists on luteinizing hormone (LH) release in vivo.
  • To determine the specific site of action for beta-blocker-induced changes in LH.

Main Methods:

  • Orchidectomized rats were treated with varying doses of propranolol and bornaprolol (FM-24).
  • Plasma LH levels, interpulse intervals, and amplitudes were measured.
  • Binding assays were performed on pituitary dopamine and hypothalamic alpha 1-adrenergic receptors.

Main Results:

Related Experiment Videos

  • Beta-blockers significantly depressed plasma LH levels in a dose-dependent manner.
  • These effects occurred without significant alterations in pulsatile LH release patterns.
  • Significant reduction in LH was observed at doses inhibiting >93% of pituitary beta-adrenergic binding, with no impact on dopamine or alpha 1-adrenergic receptors.

    • Conclusions:

    • Beta-blockers can lower LH release in vivo.
    • The pituitary beta-adrenergic receptor appears to be the primary site of action for this effect.