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Updated: Feb 23, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

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Paediatric optic neuritis: factors leading to unfavourable outcome and relapses

Delphine Averseng-Peaureaux1, Marie Mizzi2, Helene Colineaux3

  • 1Department of Neurology, Hôpital Pierre Paul Riquet, CHU Purpan, Toulouse, France.

The British Journal of Ophthalmology
|September 15, 2017
PubMed

Insights

Children aged 10+ with optic neuritis (ON) and optic disc pallor face poorer visual recovery, especially those diagnosed with multiple sclerosis (MS). Early identification aids treatment adaptation.

Area of Science:

  • Pediatric Neurology
  • Ophthalmology
  • Neuroimmunology

Background:

  • Optic neuritis (ON) in children can lead to long-term visual impairment and is sometimes associated with chronic relapsing diseases like multiple sclerosis (MS).
  • Identifying prognostic factors for poor visual recovery and disease relapse is crucial for managing pediatric ON.

Purpose of the Study:

  • To determine prognostic factors linked to suboptimal visual recovery and chronic relapsing conditions in children experiencing their first episode of optic neuritis.
  • To inform potential treatment strategies and guide future research in pediatric ON management.

Main Methods:

  • A multicenter retrospective study analyzed data from 102 children with a first ON episode (1990-2012).
  • Poor visual recovery was defined by visual acuity outcomes, and disease relapse was a secondary endpoint.
  • Statistical analysis identified factors associated with visual recovery and MS diagnosis.

Main Results:

  • Complete visual acuity recovery at 1 year was 71%, but significantly lower (27%) in children with MS.
  • Factors associated with poor visual recovery included age ≥10 years, optic disc pallor, and an MS diagnosis.
  • Age ≥10 years, abnormal brain MRI, and oligoclonal banding were linked to MS diagnosis.

Conclusions:

  • Children aged 10 and older, presenting with optic disc pallor, and diagnosed with MS are at higher risk for poor visual recovery after optic neuritis.
  • Early identification of these high-risk pediatric patients can facilitate tailored treatment approaches.
  • Findings support the need for prospective studies to optimize treatment protocols for pediatric optic neuritis.
Abstract

Keywords:
demyelinationmultiple sclerosisoptic neuritispediatricprognostic factors

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