Related Experiment Video
Updated: Feb 23, 2026

Author Spotlight: Exploring Heat Shock Proteins in Malaria and Tuberculosis Infections
Published on: March 8, 2024
Heat Shock Proteins in Histoplasma and Paracoccidioides
Levi G Cleare1, Daniel Zamith-Miranda1, Joshua D Nosanchuk2
1Department of Medicine (Division of Infectious Diseases) and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Abstract:
Heat shock proteins (Hsps) are highly conserved biomolecules that are constitutively expressed and generally upregulated in response to various stress conditions (biotic and abiotic). Hsps have diverse functions, categorizations, and classifications. Their adaptive expression in fungi indicates their significance in these diverse species, particularly in dimorphic pathogens. Histoplasma capsulatum and Paracoccidioides species are dimorphic fungi that are the causative agents of histoplasmosis and paracoccidioidomycosis, respectively. This minireview focuses on the pathobiology of Hsps, with particular emphasis on their roles in the morphogenesis and virulence of Histoplasma and Paracoccidioides and the potential roles of active and passive immunization against Hsps in protection against infection with these fungi.
Related Concept Videos
Diversity of Archaea III
Other Stress Responses in Bacteria
Diversity of Archaea IV
Bacterial Protein Maturation
Molecular Chaperones and Protein Folding
The...
Responses to Heat and Cold Stress

