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A possible neurotransmitter role for CGRP in a hair-cell sensory organ
J C Adams1, E A Mroz, W F Sewell
1Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston 29425.
Brain Research
|September 1, 1987
Abstract:
We report that calcitonin gene-related peptide (CGRP) increases the discharge rate of afferent fibers innervating hair cells in the lateral line organ of Xenopus laevis. We have localized CGRP-like immunoreactivity in small, presumably efferent, fibers innervating the lateral line organ. In addition to providing evidence for a neurotransmitter role for CGRP in a sensory system, these results may help explain the non-cholinergic excitatory effect seen with efferent stimulation in this and other hair cell organs such as the inner ear.