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Genetic Variants of RAMP2 and CLR are Associated with Stroke

Teruhide Koyama1, Nagato Kuriyama1, Etsuko Ozaki1

  • 1Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine.

Journal of Atherosclerosis and Thrombosis
|September 15, 2017
PubMed

Insights

This study explored the link between adrenomedullin (ADM) receptor genes, RAMP2 and CLR, and stroke risk. One CLR gene variant (rs574603859) showed a protective association with stroke, suggesting a role in vascular homeostasis.

Area of Science:

  • Genetics and cardiovascular disease research.
  • Investigating the genetic underpinnings of stroke risk.

Background:

  • Stroke is closely linked to vascular homeostasis, influenced by genetic and environmental factors.
  • Adrenomedullin (ADM) has vasoprotective functions, but its receptor system in humans is understudied.
  • The ADM receptor consists of calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs).

Purpose of the Study:

  • To analyze single nucleotide polymorphisms (SNPs) in RAMP2 and CLR genes for association with stroke.
  • To investigate potential gene-environment interactions influencing stroke risk.
  • To explore the role of the ADM receptor system in human stroke pathogenesis.

Main Methods:

  • Utilized cross-sectional data from 14,087 participants in the Japan Multi-Institutional Collaborative Cohort Study.
  • Genotyped participants for SNPs in RAMP2 and CLR genes.
  • Performed hypothesis-based association analysis between stroke prevalence and selected SNPs in RAMP2 and CLR.

Main Results:

  • Five SNPs (rs77035639, rs3815524, rs75380157, rs147565266, and rs753152) showed no significant association with common comorbidities.
  • One CLR SNP (rs574603859) demonstrated a significantly lower odds ratio for stroke (0.238), suggesting a protective effect.
  • Other analyzed SNPs exhibited higher odds ratios for stroke association.

Conclusions:

  • This is the first study to examine the association between ADM receptor genes (RAMP2, CLR) and stroke in humans, considering gene-environment interactions.
  • The findings highlight a potential protective role of a specific CLR gene variant in stroke.
  • Further research is warranted to elucidate the precise mechanisms underlying the ADM receptor's influence on stroke risk.
Abstract

Keywords:
AdrenomedullinCalcitonin-receptor-like receptorReceptor activity-modifying protein 2Stroke

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