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Biomedical Applications of Polyhydroxyalkanoates.

Subhasree Ray1,2, Vipin Chandra Kalia1,2

  • 1Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India.

Indian Journal of Microbiology
|September 15, 2017
PubMed
Summary
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Microbes produce polyhydroxyalkanoates (PHA) as an energy reserve under stress. These bioplastics offer biodegradability and biocompatibility, making them ideal for diverse biomedical applications.

Area of Science:

  • Biotechnology
  • Polymer Science
  • Microbiology

Background:

  • Microbes synthesize polyhydroxyalkanoates (PHA) under nutrient-limited and high carbon conditions.
  • PHAs serve as intracellular carbon and energy storage granules.
  • These biopolymers exhibit properties analogous to conventional synthetic plastics.

Purpose of the Study:

  • To highlight the microbial production of polyhydroxyalkanoates (PHA).
  • To emphasize the unique properties of PHAs, including biodegradability, biocompatibility, and non-toxicity.
  • To explore the potential of PHAs in various biomedical applications.

Main Methods:

  • Microbial cultivation under induced stress conditions (nutrient limitation, high carbon).
  • Isolation and characterization of PHA granules.
Keywords:
AntibacterialsBiocontrol agentsBiodegradable implantsDrug carriersMemory enhancerTissue engineering

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  • Evaluation of PHA properties (biodegradability, biocompatibility, toxicity).
  • Assessment of PHA suitability for medical applications through literature review and property analysis.

    • Main Results:

    • Polyhydroxyalkanoates (PHA) are microbial biopolyesters produced under specific environmental stresses.
    • PHAs possess physical and chemical properties similar to synthetic plastics.
    • Key characteristics include biodegradability, biocompatibility, and inherent non-toxicity.

    Conclusions:

    • Polyhydroxyalkanoates (PHA) are versatile biopolymers with significant potential in the biomedical field.
    • Their properties make them suitable for applications such as drug delivery, tissue engineering, and biodegradable medical devices.
    • Further research can unlock the full therapeutic and clinical utility of PHAs.