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Everolimus-associated Acute Kidney Injury in Patients with Metastatic Breast Cancer
A Chandra1, N S Rao1, K P Malhotra2
1Department of Nephrology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Indian Journal of Nephrology
|September 15, 2017
Summary
Everolimus (Evl) can cause kidney injury in breast cancer patients. Promptly stopping Evl treatment led to recovery of normal kidney function in two reported cases.
Area of Science:
- Oncology
- Nephrology
- Pharmacology
Background:
- Everolimus (Evl) is a mTOR inhibitor used with aromatase inhibitors for hormone receptor-positive metastatic breast cancer.
- Evl-induced acute kidney injury (AKI) is known in other cancers, like renal cell carcinoma.
- Previous reports of Evl-associated nephrotoxicity in breast cancer patients are rare.
Observation:
- This report details two cases of Evl-associated nephrotoxicity in patients undergoing treatment for metastatic breast cancer.
- One patient's renal biopsy confirmed acute tubular necrosis as the cause of kidney injury.
- Both patients experienced kidney function improvement after discontinuing everolimus.
Findings:
- Everolimus treatment for metastatic breast cancer can lead to acute kidney injury.
- Acute tubular necrosis is a potential histopathological finding in Evl-induced nephrotoxicity.
- Discontinuation of everolimus is an effective strategy for managing Evl-associated kidney injury.
Implications:
- Clinicians should monitor for kidney dysfunction in breast cancer patients treated with everolimus.
- Early recognition and withdrawal of everolimus may prevent long-term renal damage.
- This highlights the importance of considering drug-induced nephrotoxicity in cancer patients with new-onset kidney problems.
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