Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insomnia01:27

Insomnia

512
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
512
Management of Insomnia01:19

Management of Insomnia

732
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
732
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

468
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
468
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

977
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
977
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

682
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
682
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.1K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic Effects of Tetrandrine with Posaconazole Against Aspergillus fumigatus.

Microbial drug resistance (Larchmont, N.Y.)·2017
Same author

A novel NHS mutation causes Nance-Horan Syndrome in a Chinese family.

BMC medical genetics·2017
Same author

Positively charged polypeptide nanogel enhances mucoadhesion and penetrability of 10-hydroxycamptothecin in orthotopic bladder carcinoma.

Journal of controlled release : official journal of the Controlled Release Society·2017
Same author

Methods used to study the oligomeric structure of G-protein-coupled receptors.

Bioscience reports·2017
Same author

Patterns of Early Rejection in Renal Retransplantation: A Single-Center Experience.

Journal of immunology research·2017
Same author

Utility and safety of tolvaptan in cirrhotic patients with hyponatremia: A prospective cohort study.

Annals of hepatology·2017
Same journal

Assessing the Accuracy of Diagnostic Tests.

Shanghai archives of psychiatry·2019
Same journal

Hypokalemia Caused by Quetiapine and Risperidone Treatment in Schizophrenia: A Case Report.

Shanghai archives of psychiatry·2019
Same journal

Posterior Fossa Arachnoid Cyst Presenting as Negative Symptoms of Psychosis.

Shanghai archives of psychiatry·2019
Same journal

Research Status and Strategies for Cognitive Function in Schizophrenia.

Shanghai archives of psychiatry·2019
Same journal

The Effect of Repetitive Transcranial Magnetic Stimulation on the Reinstatement of Methamphetamine-Induced Conditioned Place Preference in Rats.

Shanghai archives of psychiatry·2019
Same journal

Comparison of Olanzapine versus Other Second-Generation Antipsychotics in the Improvement of Insight and Medication Discontinuation Rate in Schizophrenia.

Shanghai archives of psychiatry·2019
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K

Changes in Cognitive Function in Patients with Primary Insomnia.

Hui Guo1, Meijie Wei1, Wantao Ding1

  • 1The 7th People's Hospital, Wenzhou, Zhejiang, China.

Shanghai Archives of Psychiatry
|September 15, 2017
PubMed
Summary
This summary is machine-generated.

Patients with primary insomnia exhibit cognitive impairment, particularly in memory and executive functions. The severity of insomnia correlates with the extent and severity of cognitive deficits.

Keywords:
cognitive functionepisodic memoryinfluencing factorsprimary insomnia

More Related Videos

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.1K
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K

Related Experiment Videos

Last Updated: Feb 23, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.1K
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Sleep Medicine

Background:

  • Cognitive impairment in primary insomnia lacks sufficient neuropsychological evidence.
  • Further research is necessary to understand the cognitive impact of insomnia.

Purpose of the Study:

  • To quantitatively assess cognitive functioning changes in individuals with primary insomnia.
  • To compare cognitive performance between primary insomnia patients and healthy controls.

Main Methods:

  • 40 primary insomnia patients and 48 healthy controls were evaluated.
  • The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality.
  • Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and an episodic memory test.

Main Results:

  • Insomnia patients scored significantly lower on MoCA sections including naming, immediate memory, delayed recall, and overall score compared to controls.
  • Higher insomnia severity correlated with broader and more severe cognitive impairments across multiple MoCA domains.
  • Age and education level were significantly correlated with various cognitive functions in primary insomnia patients.

Conclusions:

  • Primary insomnia is associated with demonstrable cognitive impairment.
  • Cognitive deficits in primary insomnia are dose-dependent, worsening with increased insomnia severity.
  • These findings highlight the significant impact of insomnia on cognitive health.