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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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[Factor V congenital deficiency: about a case]

Saloua Boujrad1, Brahim El Hasbaoui1, Hanae Echahdi1

  • 1Service de Pédiatrie, Hôpital Militaire d'Instruction Mohamed V, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.

The Pan African Medical Journal
|September 15, 2017
PubMed

Factor V congenital deficiency is a rare coagulation disorder initially described by Owren in 1947 and known as para hemophilia. It is transmitted through autosomal-recessive inheritance and homozygous cases are usually symptomatic. Factor V is an essential cofactor in the conversion of prothrombin to thrombin by activated factor X. In the absence of factor V, thrombin generation is slowed down and fibrin formation is delayed. This results in a bleeding tendency. We report a case of factor V congenital deficiency in an infant with recurrent epistaxis.

Keywords:
Factor V congenital deficiencycircumcisionepistaxisfresh frozen plasma

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