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Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...

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Related Experiment Video

Updated: Feb 23, 2026

In Vivo Imaging Systems IVIS Detection of a Neuro-Invasive Encephalitic Virus

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Published on: December 2, 2012

Post-ivermectin encephalopathy in Senegal: a case report.

Daniel Gams Massi¹, Mohamed Lelouma Mansare¹, Mariétou Traoré¹

¹Cheikh Anta Diop University, Neurosciences Department, Fann National Teaching Hospital, Dakar, Senegal.

The Pan African Medical Journal

|September 15, 2017

Summary

A case study highlights severe neurological side effects of ivermectin, including encephalopathy and blindness, after an overdose. Prompt corticosteroid treatment aided recovery, emphasizing careful drug administration.

Area of Science:

Neurology
Infectious Diseases
Pharmacology

Background:

Ivermectin is an antiparasitic medication crucial for treating onchocerciasis and lymphatic filariasis.

Keywords:

Ivermectin corticosteroids encephalopathy

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While effective, ivermectin can cause serious adverse events, including post-ivermectin encephalopathy, necessitating emergency medical care.