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Total Oxidant and Antioxidant Status in Prepubertal Children with Obesity

Grażyna Rowicka1, Hanna Dyląg1, Jadwiga Ambroszkiewicz2

  • 1Nutrition Department, Institute of Mother and Child, Warsaw, Poland.

Oxidative Medicine and Cellular Longevity
|September 15, 2017
PubMed

Insights

Obese children show signs of oxidative stress, indicated by higher oxidant capacity and lower antioxidant capacity. Early intervention is crucial to prevent long-term health issues related to free radical damage.

Area of Science:

  • Pediatrics
  • Biochemistry
  • Metabolic Disorders

Background:

  • Obesity is linked to increased free radical production.
  • Uncontrolled free radicals can cause oxidative stress and health complications.
  • The presence of oxidative stress in obese prepubertal children requires investigation.

Purpose of the Study:

  • To evaluate the presence and extent of oxidative stress in obese prepubertal children.
  • To compare oxidative stress markers between obese and nonobese children.

Main Methods:

  • The study included 83 children aged 2-10 years (62 obese, 21 controls).
  • Serum levels of total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidized low-density lipoprotein (ox-LDL), lipids, glucose, and C-reactive protein (CRP) were measured.
  • Oxidative stress index (OSI) was calculated.

Main Results:

  • Obese children exhibited significantly higher TOC and lower TAC compared to controls.
  • The oxidative stress index (OSI) was significantly higher in the obese group.
  • Obese children had higher median CRP and lower HDL cholesterol levels. TAC negatively correlated with ox-LDL, and obesity duration positively correlated with TOC.

Conclusions:

  • Obesity-related oxidative stress is present even in prepubertal children.
  • Early diagnosis and treatment of obesity are vital for preventing free radical damage and associated complications.
Abstract

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