Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lead effects in the chick during selenium deficiency.

C McGowan1, W E Donaldson

  • 1Toxicology Program, North Carolina State University, Raleigh 27695-7608.

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with long-term function in cats treated with femoral head and neck excision.

The Journal of small animal practice·2025
Same author

Is weight-bearing as tolerated safe after proximal tibial metaphyseal autogenous bone harvest? A systematic review and meta-analysis.

International journal of oral and maxillofacial surgery·2024
Same author

A survey investigating owner perceptions and management of firework-associated fear in dogs in the Greater Sydney area.

Australian veterinary journal·2024
Same author

Challenges in recruiting children to a multidrug-resistant TB prevention trial.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021
Same author

Trends in proportion of older HIV-infected people in care in Latin America and the Caribbean: a growing challenge.

Epidemiology and infection·2018
Same author

Equine metabolic syndrome.

The Veterinary record·2015
Same journal

Pharmacokinetics of triclabendazole in rabbits.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993
Same journal

Characterization of the alpha 1B-adrenergic receptors of chicken hepatocytes. Signal transduction and actions.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993
Same journal

Evolution of neuropeptide Y and its related peptides.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993
Same journal

Binding of agonists and antagonists to the porcine adipose tissue beta-adrenergic receptor(s).

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993
Same journal

Effect of diflubenzuron on incorporation of [3H]-N-acetylglucosamine ([3H]NAGA) into chitin in the intact integument from the newly molted American cockroach Periplaneta americana.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993
Same journal

Effect of diflubenzuron on the incorporation of UDP-N-acetyl-[3H]glucosamine (UDP-[3H]NAGA) to chitin in permeabilized, and isolated integuments from the newly molted American cockroach Periplaneta americana.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993
See all related articles

This study found that while selenium supplementation improved growth in chicks, lead exposure hindered it. The antagonism between lead and selenium was not explained by glutathione peroxidase or non-protein sulfhydryl levels.

Area of Science:

  • Animal Nutrition
  • Toxicology
  • Biochemistry

Background:

  • Selenium (Se) and lead (Pb) are essential and toxic elements, respectively, with known interactions.
  • Understanding these interactions is crucial for animal health and environmental safety.

Purpose of the Study:

  • To investigate the effects of lead and selenium supplementation on chick growth and specific biochemical markers.
  • To elucidate the mechanisms underlying the antagonism between lead and selenium.

Main Methods:

  • Growing chicks were fed diets with varying levels of lead (0 or 2000 ppm) and selenium (0 or 0.1 ppm).
  • Growth performance, Se-dependent glutathione peroxidase (GSH-Px) activity, and non-protein sulfhydryl (NPSH) concentrations were measured in liver, kidney, and muscle tissue.

Related Experiment Videos

Main Results:

  • Selenium supplementation enhanced chick growth in the absence of lead but not in its presence.
  • Lead exposure significantly reduced growth regardless of selenium levels.
  • Selenium increased GSH-Px activity, while lead had no effect on it.
  • Lead increased NPSH concentrations in multiple tissues, whereas selenium did not alter NPSH levels.

Conclusions:

  • The antagonistic effects of lead on selenium's growth-promoting properties are evident.
  • The observed antagonism between lead and selenium is not mediated by alterations in GSH-Px or NPSH metabolism.
  • Further research is needed to understand the precise biochemical pathways involved in lead-selenium interactions.