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Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
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Structure-function relationships in the visual system in multiple sclerosis: an MEG and OCT study.

Prejaas Tewarie1,2, Lisanne J Balk1, Arjan Hillebrand3

  • 1Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands.

Annals of Clinical and Translational Neurology
|September 15, 2017
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis patients show a link between retinal layer thickness and visual cortex connectivity. Optic neuritis impacts this relationship, especially in alpha bands and outer retinal layers.

Keywords:
Functional connectivitymagnetoencephalographymultiple sclerosisneuronal oscillationsoptical coherence tomographyvisual cortex

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Medical Imaging

Background:

  • Multiple Sclerosis (MS) can affect the visual system.
  • Optic Neuritis (ON) is a common complication in MS.
  • Retinal layer integrity may correlate with visual pathway function.

Purpose of the Study:

  • To investigate the relationship between retinal layer integrity and visual cortex electrophysiology.
  • To assess functional connectivity (FC) and neuronal activity in MS patients with ON.
  • To explore how MS-related ON influences visual network function.

Main Methods:

  • Multi-modal study combining Optical Coherence Tomography (OCT) and Magnetoencephalography (MEG).
  • Collected OCT data from optic discs and macular regions.
  • Analyzed resting-state MEG data for relative power and Phase Lag Index (PLI) to estimate neuronal activity and FC.

Main Results:

  • Significant correlations found between retinal layer thickness and visual cortex relative power and FC.
  • MS-related ON particularly influenced alpha band connectivity and outer macular layers.
  • In non-ON patients, relationships were stronger in lower frequency bands (theta, delta) and inner/outer retinal layers.

Conclusions:

  • Visual cortex functional connectivity (FC) is more affected by MS-related ON than neuronal activity.
  • Findings suggest FC plasticity plays a role in visual network changes post-ON.
  • Highlights the link between retinal structure and brain function in MS.