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Is there any association between vitamin D levels and isolated coronary artery ectasia?
Serkan Ciftci1, Fatma Nihan Turhan Caglar1, İsmail Biyik2
1Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
Insights
Low vitamin D and high parathormone levels are linked to coronary artery ectasia (CAE). However, vitamin D levels did not correlate with the extent of CAE in this study.
Area of Science:
- Cardiology
- Endocrinology
- Nutritional Science
Background:
- Low vitamin D levels are hypothesized to correlate with coronary artery diseases.
- Coronary artery ectasia (CAE) is linked to various conditions including atherosclerosis and immunological disorders.
Purpose of the Study:
- To investigate the association between vitamin D and parathormone levels and isolated coronary artery ectasia (CAE).
- To determine if vitamin D levels correlate with the extent of CAE.
Main Methods:
- A study involving 93 participants: 47 with isolated CAE and 46 healthy controls.
- Serum vitamin D and parathormone levels were measured using chemiluminescence.
- Coronary artery ectasia extent was assessed using the Markis classification.
Main Results:
- Patients with isolated CAE exhibited significantly lower vitamin D levels compared to controls (9.15 ±4.4 ng/ml vs. 13.35 ±5.9 ng/ml, p < 0.001).
- Parathormone levels were significantly higher in the CAE group (61.4 ±31.6 vs. 48.7 ±25.5, p < 0.036).
- No significant association was found between vitamin D levels and the extent of CAE (p = 0.23).
Conclusions:
- Lower vitamin D and higher parathormone levels are associated with isolated coronary artery ectasia.
- The extent of coronary artery ectasia is not associated with vitamin D levels.
Introduction:
It has been postulated that low vitamin D levels are associated with coronary artery diseases. Coronary artery ectasia (CAE) is associated with atherosclerosis, congenital cardiac defects, immunological diseases and connective tissue diseases. In this study, we aimed to investigate whether there is an association between vitamin D and parathormone levels and isolated coronary artery ectasia and its extent.
Material And Methods:
The study included 93 participants: 47 patients (35 male, 12 female) with isolated CAE and 46 subjects (28 male, 18 female) with normal coronary arteries. Demographic characteristics of patients and controls were obtained from medical records, and Markis scores of patients were calculated. Serum vitamin D and parathormone levels were quantitatively measured by the paramagnetic particle chemiluminescence method.
Results:
Serum vitamin D levels were found to be significantly lower in patients with isolated CAE than the control group (9.15 ±4.4 ng/ml, 13.35 ±5.9 ng/ml, p < 0.001). Parathormone levels were significantly higher in the CAE group than the control group (61.4 ±31.6, 48.7 ±25.5, p < 0.036). However, the study revealed no association between serum vitamin D levels and the extent of CAE according to the Markis classification (p = 0.23).
Conclusions:
This study revealed that lower vitamin D levels and higher parathormone levels were associated with isolated CAE, but there was no association between vitamin D levels and the extent of CAE.
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