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Updated: Feb 23, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
A transition-metal-free fast track to flavones and 3-arylcoumarins
Mostafa Golshani1, Mehdi Khoobi, Nafiseh Jalalimanesh
1Nanobiomaterials group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 141761411, Iran. mkhoobi@tums.ac.ir Mehdi.khoobi@gmail.com.
Abstract:
A highly regioselective and transition-metal free one-pot arylation of chromenones with arylboronic acids has been achieved employing K2S2O8. The procedure consists of a sequence of some reactions including an arylation/decarboxylation cascade and proceeds well in aqueous media to afford biologically interesting flavones and 3-arylcoumarins. This method exhibited excellent selectivity and functional group tolerance under mild conditions. The reaction also showed perfect efficacy for the preparation of styryl coumarins.
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