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Updated: Feb 23, 2026

02:33
Transconjunctival Approach for Injection into the Rat Optic Nerve
Published on: April 4, 2025
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[Indications and technique for transconjunctival optic nerve sheath fenestration : Video article]
W A Lagrèze1, N Gross2, J Biermann2
1Klinik für Augenheilkunde, Medizinische Fakultät, Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland. wolf.lagreze@uniklinik-freiburg.de.
Summary
Optic nerve sheath fenestration is a safe surgical option for pseudotumor cerebri syndrome when vision is threatened. This procedure offers an alternative to shunts, particularly when ophthalmological symptoms are primary.
Area of Science:
- Ophthalmology
- Neurosurgery
- Medical Science
Background:
- Pseudotumor cerebri syndrome (PTCS) often requires intervention to manage increased intracranial pressure.
- Ventricular shunts are a common treatment, but optic nerve sheath fenestration (ONSF) is considered when visual symptoms dominate.
Purpose of the Study:
- To review the indications, surgical technique, and outcomes of ONSF for PTCS.
- To compare ONSF with alternative treatments for PTCS-related vision loss.
Main Methods:
- Systematic literature search and analysis of surgical cases.
- Documentation and description of the medial transconjunctival orbitotomy technique for ONSF.
- Review of surgical microscope use with confocal illumination for optic nerve visualization.
Main Results:
- Transconjunctival ONSF is a safe procedure for reducing visual loss in PTCS.
- ONSF can be an effective alternative to shunts or venous stents in select patients.
Conclusions:
- ONSF provides a valuable option for preserving vision in PTCS patients with predominant ophthalmological symptoms.
- This minimally invasive approach offers a viable alternative to more invasive procedures.
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